منابع مشابه
Practical Human Cytogenetics
ALTHOUGH attempts at establishing the human chromosome number dates from early in this century, it was not until 1957 when improvements in techniques became available that human cytogenetics became established as a laboratory discipline. Since 1959, many clinical disorders ranging from abnormalities of sexual, physical and intellectual development, pregnancy wastage, leukaemia and tumours, have...
متن کاملSome clinical aspects of human cytogenetics.
EXPECTATIONS of discoveries, relating chromosome aberrations in tumour cells to the type of growth, benign or malignant, have not often been justified. Cultures from most tumours have normal karyotypes and in leukemias, for example, the abnormalities found, except for the famous Philadelphia deletion in the chronic myeloid type, are not consistent or characteristic. Moreover, a mongol with leuk...
متن کاملHuman Cytogenetics: from Classical to Molecular Karyotyping
The establishment of human diploid chromosome number (Tjio and Levan, 1956), have led to the foundations of human cytogenetics. Since then, due to the rapid developments of new techniques for chromosome analysis, many other chromosome disorders were recognized. The introduction of banding techniques, yielding a highly reproducible banding pattern, allowed the reliable identification of every si...
متن کاملHuman molecular cytogenetics: From cells to nucleotides
The field of cytogenetics has focused on studying the number, structure, function and origin of chromosomal abnormalities and the evolution of chromosomes. The development of fluorescent molecules that either directly or via an intermediate molecule bind to DNA has led to the development of fluorescent in situ hybridization (FISH), a technology linking cytogenetics to molecular genetics. This t...
متن کاملHistorical prospective of human cytogenetics: from microscope to microarray.
After the fundamental discovery in 1956 that normal human cells contain 46 chromosomes, clinical cytogenetics was born and studies into the relation of chromosomal defects and disease could begin. Although many technical advances have been made over this long period, including the introduction of molecular techniques, until now, all cytogenetic studies have been performed through regular micros...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1975
ISSN: 1468-6244
DOI: 10.1136/jmg.12.3.315-a